Sigma Receptor

Receptor

Sigma Receptor

Sigma Receptor Isoform Specific Products:

Sigma Receptor Related Products (146)
Sigma Receptor Isoform Comparison

By Effects:	Inhibitors (10) Ligand (1) Agonists (43) Antagonists (47) Activators (7) Modulators (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-RS12908

SIGMAR1 Human Pre-designed siRNA Set A	Inhibitor
SIGMAR1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIGMAR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIGMAR1 Human Pre-designed siRNA Set A SIGMAR1 Human Pre-designed siRNA Set A

HY-161873

PW507	Antagonist
PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a K_i of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN).

HY-117420

CM764	Activator
CM764 is an activator for sigma receptor with K_i of 86.6 and 3.5 nM for sigma-1 receptor and sigma-2 receptor. CM764 increases cytoplasmic calcium, NAD⁺/NADH, and ATP levels, and decreases the concentration of ROS.

HY-135608

BD-1008	Antagonist
BD-1008 is a selective antagonist of the sigma receptors, demonstrating a binding affinity of K? = 2 ± 1 nM for the sigma-1 receptor and exhibiting fourfold selectivity over the sigma-2 receptor.

HY-149854A

AB21 oxalate	Antagonist
AB21 oxalate is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 oxalate has the effect of reducing mechanical hypersensitivity.

HY-116463C

(2R,3R)-E1R	Agonist	98.79%
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

HY-120360

CB-64D	Agonist
CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with K_i of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH.

HY-119196

Caprospinol	Ligand
Caprospinol (SP-233) is a steroid compound candidate based on the structure of 22R-hydroxycholesterol. It has multiple mechanisms of neuroprotection, including binding to β-amyloid protein (Aβ(42)), interacting with the mitochondrial respiratory chain, clearing Aβ(42) monomers, and acting as a σ-1 receptor ligand. It can cross the blood-brain barrier in vivo and restore cognitive impairment, and has the potential to inhibit Alzheimer's disease.

HY-149854

AB21	Antagonist
AB21 is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity.

HY-151950

Antidepressant agent 3
Antidepressant agent 3 is an orally active antidepressant agent. Antidepressant agent 3 exhibits antidepressant, anxiolytic, performance enhancing and nootropic activities.

HY-158693

WLB-87848	Agonist
WLB-87848 is a selective, orally active, and blood-brain barrier (BBB) permeable σ1 receptor agonist with the K_i of 9 nM. WLB-87848 rescues recognition memory impairment.

HY-B1055R

Pentoxyverine (citrate) (Standard)	Agonist
Pentoxyverine (citrate) (Standard) is the analytical standard of Pentoxyverine (citrate). This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[4].

HY-111081C

(±)-PPCC oxalate	Agonist
(±)-PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with K_i of 1.5 nM. (±)-PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats.

HY-14222

UMB24	Antagonist
UMB24 is a potent antagonist of σ2 receptor, with K_i values of 170 nM anf 322 nM for σ2 receptor and σ1 receptor, respectively. UMB24 attenuats cocaine-induced convulsions and locomotor activity, but not lethality.

HY-117731

UKH-1114	Agonist
UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a K_i value of 46 nM, showing antimechanical hypersensitivity effects. UKH-1114 alleviates mechanical hypersensitivity caused by nerve injury without any movement disorders in mice. UKH-1114 is promising for research of neuropathic pain.

HY-156124

Sigma-2 Radioligand 1
Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts.

HY-B0765R

Dehydroepiandrosterone sulfate sodium (Standard)	Activator
Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium salt (Standard) is the analytical standard of Dehydroepiandrosterone sulfate sodium salt (HY-B0765). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate has both non-competitive antagonist activity of GABA_A receptor and agonist activity of σ₁ receptor. Dehydroepiandrosterone sulfate can partially penetrate the blood-brain barrier, inhibit GABA_A receptor-mediated chloride influx, enhance NMDA receptor activity through σ₁ receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality.

HY-14220

CB-184
CB-184 is a selective ligand for sigma-2 (σ2), with K_i values of 7436 nM for σ1 and 13.4 nM for σ2. CB-184 promotes apoptosis and has antitumor activity.

HY-149804A

S1R agonist 2 hydrochloride	Agonist	≥98.0%
S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity.

HY-16996

BD-1047	Antagonist
BD-1047 is a selective functional antagonist of sigma receptors. BD-1047 attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches.

PRE-084 hydrochloride	Sigma 1 Receptor		99.92%
BD-1047 dihydrobromide	Sigma 1 Receptor		98.17%
Dehydroepiandrosterone sulfate	Sigma 1 Receptor		99.93%
Siramesine hydrochloride	Sigma 1 Receptor		99.69%
Dehydroepiandrosterone sulfate sodium	Sigma 1 Receptor		99.96%
Cutamesine dihydrochloride	Sigma 1 Receptor, IC₅₀: 17.4 nM	Sigma 2 Receptor, IC₅₀: 1784 nM	98.05%
(±)-Vesamicol hydrochloride	Sigma 1 Receptor	Sigma 2 Receptor	99.81%
CT1812		Sigma 2 Receptor
Blarcamesine hydrochloride	Sigma 1 Receptor		99.87%
S1RA hydrochloride	Sigma 1 Receptor		99.94%
Glycerol phenylbutyrate		Sigma 2 Receptor	99.81%
BD1063 dhydrochloride	Sigma 1 Receptor		≥98.0%
Dimemorfan phosphate	Sigma 1 Receptor		99.87%
NE-100 hydrochloride	Sigma 1 Receptor, IC₅₀: 4.16 nM		98.20%
σ1 Receptor antagonist-1	Sigma 1 Receptor		99.87%
SKF 83959	Sigma 1 Receptor		98.94%
S1RA	human σ1R, Ki: 17 nM guinea pig σ1R, Ki: 23.5 nM	guinea pig σ2R, Ki: >1000 nM rat σ2R, Ki: 9300 nM	99.43%
Pentoxyverine citrate	σ1, Ki: 41 nM	σ2, Ki: 894 nM	99.57%
Ditolylguanidine	Sigma 1 Receptor	Sigma 2 Receptor	99.66%
Pentoxyverine	σ1, Ki: 41 nM	σ2, Ki: 894 nM	98.91%
Blarcamesine	Sigma 1 Receptor		99.51%
Sigma-1 receptor antagonist 1	Sigma 1 Receptor		98.64%
Dehydroepiandrosterone sulfate-d₆ sodium dihydrate	Sigma 1 Receptor		98.00%
Dehydroepiandrosterone sulfate (Standard)	Sigma 1 Receptor
Sigma-1 receptor antagonist 2	Sigma 1 Receptor		99.76%
BMY 14802	Sigma 1 Receptor		98.96%
E1R	Sigma 1 Receptor		99.83%
S1R agonist 2	Sigma 1 Receptor, Ki: 1.1 nM	Sigma 2 Receptor, Ki: 88 nM	≥98.0%
Dehydroepiandrosterone sulfate sodium-d₆	Sigma 1 Receptor		99.61%
Cutamesine	Sigma 1 Receptor, IC₅₀: 17.4 nM	Sigma 2 Receptor, IC₅₀: 1784 nM	99.18%
4-IBP	Sigma 1 Receptor	Sigma 2 Receptor	98.90%
S1R agonist 1	Sigma 1 Receptor, Ki: 0.93 nM	Sigma 2 Receptor, Ki: 72 nM	≥98.0%
Sigma-1 receptor antagonist 3	Sigma 1 Receptor		99.47%
Siramesine	Sigma 1 Receptor
AB10	Sigma 1 Receptor, Ki: 10 nM	Sigma 2 Receptor, Ki: 165 nM
EST64454	σ1R, Ki: 22 nM
σ1 Receptor ligand 1	σ1, Ki: 3.9 nM
SUN-1334H free base	σ1, IC₅₀: 5.46 μM
CM764	Sigma 1 Receptor, Ki: 86.6 nM	Sigma 2 Receptor, Ki: 3.5 nM
CB-64D	Sigma 1 Receptor, Ki: 3063 nM	Sigma 2 Receptor, Ki: 16.5 nM
AB21	Sigma 1 Receptor, Ki: 13 nM	Sigma 2 Receptor, Ki: 102 nM
UMB24	σ1, Ki: 322 nM	σ2, Ki: 170 nM
Dehydroepiandrosterone sulfate sodium (Standard)	Sigma 1 Receptor
Phenyltoloxamine	Sigma 1 Receptor, Ki: 160 nM
AD186	Sigma 1 Receptor, Ki: 2.7 nM	Sigma 2 Receptor, Ki: 27 nM
SW116 free base	Sigma 1 Receptor, Ki: 1055 nM	Sigma 2 Receptor, Ki: 14 nM
KSCM-1	Sigma 1 Receptor, Ki: 27.5 nM	Sigma 2 Receptor, Ki: 528 nM
Fabomotizole	Sigma 1 Receptor		99.96%
σ1 Receptor antagonist 4	σ1R, Ki: 10 nM	σ2, Ki: 370 nM

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Sigma Receptor

Sigma Receptor

Sigma Receptor Isoform Specific Products:

Sigma Receptor Isoform Specific Products:

Sigma Receptor Related Products (146)

Sigma Receptor Isoform Comparison

Sigma Receptor Related Products (146):